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임세진 교수
E-mail : sejinim@skku.edu


바이러스 감염,종양, 면역질환 모델에서의 적응성 면역반응 연구
면역항암 항체/T세포 치료제 개발 연구
면역질환 항체 치료제 개발 연구

2000-2003 포항공과대학교 생명과학과 (학사)
2003-2012 포항공과대학교 생명과학과 – 세포면역학 (박사)

2012-2019 에모리 대학교, Postdoctoral Fellow/Research Associate/Associate Scientist
2020-현재 성균관대학교 의과대학 면역학교실 조교수
주요 연구물

1. Eberhardt CS, Kissick HT, Patel MR, Cardenas MA, Prokhnevska N, Obeng RC, Nasti TH, Griffith CC, Im SJ, Wang X, Shin DM, Carrington M, Chen ZG, Sidney J, Sette A, Saba NF, Wieland A, Ahmed R.Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer.Nature (2021) 597(7875):279 PMID: 34471285 (IF: 42.778)
2. Buchwald ZS, Nasti TH, Lee J, Eberhardt CS, Wieland A, Im SJ, Lawson D, Curran W, Ahmed R, Khan MK. Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy.J Immunother Cancer. (2020)8(2):e000867 PMID: 33028691 (IF: 10.252)
3. Chang YM, Wieland A, Li ZR, Im SJ, McGuire DJ, Kissick HT, Antia R, and Ahmed R. T cell receptor diversity and lineage relationship between virus-specific CD8 T cell subsets during chronic LCMV infection. J Virol (2020) 94(20):e00935 PMID: 32759317 (IF: 4.663)
4. *Im SJ and *Ha S-J. Re-defining T-Cell Exhaustion: Subset, Function, and Regulation. Immune Netw (2020) 20(1):e2 PMID: 32158590 (Review) (IF: 3.111) (*Co-corresponding authors)
5. Im SJ, Konieczny BT, Hudson WH, Masopust D and Ahmed R. PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection. Proc Natl Acad Sci USA (2020) 117(8):4292 PMID: 32034098 (IF: 9.504)
6. Jansen CS, Prokhnevska N, Master V, Sanda M, Carlisle JW, Bilen MA, Cardenas M, Wilkinson S, Lake R, Sowalsky AG, Valanparambil RM, Hudson WH, McGuire D, Melnick K, Khan AI, Kim K, Chang YM, Kim A, Filson C, AlemozaffarM, Osunkoya AO, Mullane P, Ellis C, Akondy R, Im SJ, Kamphorst A, Reyes A, Liu Y and Kissick HT. An intra-tumoral niche maintains and differentiates stem-like CD8 T cells. Nature (2019) 576(7787):465 PMID: 31827286 (IF: 41.577)
7. Hudson WH, Gensheimer JL, Hashimoto M, Wieland A, Valanparambil RM, Li P, Lin JX, Konieczny BT, Im SJ, Freeman GJ, Leonard WJ, Kissick HT and Ahmed R. Proliferating transitory T cells with an effector-like transcriptional signature emerge from PD-1+ stem-like CD8+ T cells during chronic infection. Immunity (2019), 51(6):1043 PMID: 31810882 (IF: 19.744)
8. *Jadhav RR, *Im SJ, *Hu B, Hashimoto M, Li P, Leonard WJ, Greenleaf WJ, ☨Ahmed R and ☨Goronzy JJ. Epigenetic signature of PD-1+TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade.Proc Natl Acad Sci USA (2019), 116 (28):14113 PMID: 31227606 (IF: 9.504) (*Co-first authors, ☨Co-corresponding authors)
9. Hashimoto M, Kamphorst AO, Im SJ, Kissick HT, Pillai RN, Ramalingam SS, Araki K and Ahmed R. CD8 T cell exhaustion in chronic infection and cancer: Opportunities for interventions. Annu Rev Med (2018) 69:301. (Review) PMID: 29414259 (IF: 13.609)
10. Hashimoto M, Im SJ, Araki K and Ahmed R. Cytokine-mediated regulation of CD8 T-cell responses during acute and chronic viral infection. Cold Spring HarbPerspect Biol (2017): a028464. (Review) PMID: 29101105 (IF: 8.769)
11. Lee J, Hashimoto M, Im SJ, Araki K, Jin HT, Konieczny BT, Spies GA, McElrath MJ and Ahmed R. Adenovirus serotype 5 vaccination results in suboptimal CD4 T helper 1 responses in mice. J Virol (2017) 91(5):e01132. PMID: 28003483 (IF: 4.663)
12. Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH and Ahmed R. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature (2016) 537(7620):417. PMID: 27501248 (IF: 40.137)
- This article is highlighted in News and Views of same issue of Nature (2016) 537(7620):312.
13. *Yoon SK, *Seo YB, Im SJ, Bae SH, Song MJ, You CR, Jang JW, Yang SH, Sur YS, Song JS, Kim BM, Kim CY, Jeong SH and Sung YC. Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice. Liver Int (2015) 35(3):805. PMID: 24620920 (IF: 4.470) (*Co-first authors)
14. *Seo YB, *Im SJ, Namkoong H, Kim SW, Choi YW, Kang MC, Lim HS, Jin HT, Yang SH, Cho ML, Kim YM, Lee SW, Choi YK, Surh CD and Sung YC. Crucial roles of interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity. J Virol (2014) 88(16): 8998. PMID: 24899182 (IF: 4.439) (*Co-first authors)
15. Namgoong H, Song MY, Seo UB, Choi DH, Kim SW, Im SJ, Sung YC and Park Y. Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11. Vaccine (2014) 32(10): 1205. PMID: 23928465 (IF: 3.492)
16. Martin CE, van Leeuwen EM, Im SJ, Roopenian DC, Sung YC and Surh CD. IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R. Blood (2013) 121(22): 4484. PMID: 23610371 (IF: 9.06)
17. Im SJ, Yang SI, Yang SH, Choi DH, Choi SY, Kim HS, Jang DS, Jin KS, Chung YK, Kim SH, Paik SH, Park YC, Chung MK, Kim YB, Han KH, Choi KY and Sung YC. Natural form of noncytolytic flexible human Fc as a long-acting carrier of agonistic ligand, erythropoietin. PLoS One (2011) 6(9): e24574. PMID: 21957455 (IF: 4.092)
18. Park KS, Seo YB, Lee JY, Im SJ, Seo SH, Song MS, Choi YK and Sung YC. Complete protection against a H5N2 avian influenza virus by a DNA vaccine expressing a fusion protein of H1N1 HA and M2e. Vaccine (2011) 29(33): 5481. PMID: 21664216 (IF: 3.766)
19. Park SH, Song MY, Nam HJ, Im SJ and Sung YC. Codelivery of IL-7 Augments Multigenic HCV DNA Vaccine-induced Antibody as well as Broad T Cell Responses in Cynomolgus Monkeys. Immune Netw (2010) 10(6): 198. PMID: 21286380 (IF: 2.524)
20. Im SJ, Yang SH, Yoon SK and Sung YC. Increase of Plasma IL-12/p40 Ratio Induced by the Combined Therapy of DNA Vaccine and Lamivudine Correlates with Sustained Viremia Control in CHB Carriers. Immune Netw (2009) 9(1): 20. PMID: 20107534 (IF: 2.524)
21. Kim CY, Kang ES, Kim SB, Kim HE, Choi JH, Lee DS, Im SJ, Yang SH, Sung YC, Kim BM and Kim BG. Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation. Exp Mol Med (2008) 40(6): 669. PMID: 19116452 (IF: 2.376)
22. Kang ES, Kim CY, Kim SB, Im SJ, Yang SH, Sung YC and Kim BM. In vivo kinetics and biodistribution of HB-110, a novel HBV DNA vaccine, after administration in mice. Arch Pharm Res (2007) 30(3): 355. PMID: 17424943 (IF: 1.074)
23. Im SJ and Sung YC. Action mechanism in immunopathogenesis and clearance of HBV. Korean J Hepatol (2006) 12(2): 154. (Review, Korean) PMID: 16804340
24. Yang SH, Lee CG, Park SH, Im SJ, Kim YM, Son JM, Wang JS, Yoon SK, Song MK, Ambrozaitis A, Kharchenko N, Yun YD, Kim CM, Kim CY, Lee SH, Kim BM, Kim WB and Sung YC. Correlation of antiviral T-cell responses with suppression of viral rebound in chronic hepatitis B carriers: a proof-of-concept study. Gene Ther (2006) 13(14): 1110. PMID: 16525482 (IF: 4.782)